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il farmaco asenapina è commercializzato in italia dal ottobre del anno scorso ma in america da più tempo carico la scheda della FDA americana Food and Drug administration per quanto riguarda le indicazioni e gli effetti collaterali in america è saphris il nome commerciale.

asenapina è già presente da noi per la distribuzione ( basta chiedere in farmacia ) ma costa 142 euro ed è soggetto a piano terapeutico regionale come gli altri antipsicotici atipici. penso che con l’attuale congiuntura economica e il suo costo e l’attenzione che c’è in questo momento alla spesa farmaceutica, verrà probabilmente utilizzato su giovani psicotici non responders che abbiano una famiglia con la possibilità di sostenere la spesa autonomamente .le indicazioni di seguito della FDA presentano un lungo elenco di pazienti in cui il farmaco non può essere utilizzato, e la possibile concomitanza con alcool e droghe viene considerata come condizione di non utilizzo cosi come demenza e pluriterapia nell’anziano.

Generic Name: asenapine (a SEN a peen)
Brand Names: Saphris

Saphris is an antipsychotic medication. It works by changing the actions of chemicals in the brain.

Saphris is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder (manic depression) in adults.

Saphris may also be used for other purposes not listed in this medication guide.

Important information about Saphris

Saphris is not for use in psychotic conditions related to dementia. Saphris may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. While you are taking Saphris, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking asenapine. Saphris may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. 

Before taking Saphris, tell your doctor if you have liver disease, heart disease, high blood pressure, seizures, low white blood cell counts, diabetes, trouble swallowing, or a history of breast cancer, heart attack, stroke, or “Long QT syndrome.”

Drinking alcohol can increase some of the side effects of Saphris. Stop taking Saphris and call your doctor at once if you have fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, restless muscle movements in your face or neck, tremor (uncontrolled shaking), trouble swallowing, feeling light-headed, or fainting.

Before taking Saphris

Saphris is not for use in psychotic conditions related to dementia. Saphris may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

You should not use Saphris if you are allergic to asenapine.

To make sure you can safely take Saphris, tell your doctor if you have any of these other conditions:

• liver disease;
• heart disease, high blood pressure, heart rhythm problems;
• a history of heart attack or stroke;
• a history of breast cancer;
• seizures or epilepsy;
• diabetes (asenapine may raise your blood sugar);
• trouble swallowing;
• Parkinson’s disease;
• a history of low white blood cell (WBC) counts; or
• a personal or family history of”Long QT syndrome.”

Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking Saphris, do not stop taking it without your doctor’s advice.

FDA pregnancy category C. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Asenapine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give Saphris to anyone younger than 18 years old without the advice of a doctor.